abstract：OBJECTIVES:B cells play important roles in inflammatory diseases. This study was aimed at examining the frequency of different subsets of B cells in patients with non-traumatic osteonecrosis of the femoral head (NONFH). METHODS:The percentages of the different subsets of circulating B cells in 28 patients with steroid...

journal_title：International immunopharmacology

authors： Zhang H,Xiao F,Liu Y,Zhao D,Shan Y,Jiang Y

更新日期：2014-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. Gallium nitrate has been reported to reserve immunosuppressive activities. Therefore, we assessed the therapeutic effects of gallium nitrate in the mouse model of developed type II collagen-induced arthritis (CIA). CIA was induced by bovine type I...

journal_title：International immunopharmacology

authors： Choi JH,Lee JH,Roh KH,Seo SK,Choi IW,Park SG,Lim JG,Lee WJ,Kim MH,Cho KR,Kim YJ

更新日期：2014-05-01 00:00:00

abstract：:The effects of TGF-β on dendritic cells (DCs) in the tumor microenvironment are not well-understood. In this study, we investigated the effect of TGF-β on the induction of programmed death ligand-1 (PD-L1) expression in DCs and the underlying mechanism, and we further investigated the influence of the DCs with PD-L1 e...

journal_title：International immunopharmacology

authors： Song S,Yuan P,Wu H,Chen J,Fu J,Li P,Lu J,Wei W

更新日期：2014-05-01 00:00:00

abstract：:Evidence shows that psychosocial stress exacerbates asthma, but there is little intervention to alleviate negative effects of psychosocial stress on asthma. We investigated the role of icariin in anti-inflammation and anti-anxiety potential in a murine model combined psychosocial stress with allergic exposure. The res...

journal_title：International immunopharmacology

authors： Li B,Duan X,Xu C,Wu J,Liu B,Du Y,Luo Q,Jin H,Gong W,Dong J

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The T-cell immunoglobulin and mucin domain-(Tim)-1 molecule and Tim-3 are mainly expressed on activated T helper (Th) 2 and Th1 cells, respectively, and have been implicated in the pathogenesis of some autoimmune diseases. Immune thrombocytopenia (ITP) is a common autoimmune disorder, and the complex dysregu...

journal_title：International immunopharmacology

authors： Zhang XM,Shan NN,Sun M,Wang X,Feng XM,Liu X,Li Y,Yuan D,Ding M

更新日期：2014-03-01 00:00:00

abstract：:Zingerone, one of the active components of ginger, is a phenolic alkanone with antioxidant and anti-inflammatory properties. In the present study, we analyzed the role of zingerone against RAW 264.7 cells and acute lung injury induced by lipopolysaccharide (LPS) in mice. RAW cells or BALB/c mice were pretreated with z...

journal_title：International immunopharmacology

authors： Xie X,Sun S,Zhong W,Soromou LW,Zhou X,Wei M,Ren Y,Ding Y

更新日期：2014-03-01 00:00:00

abstract：:To study the anti-inflammation effect of Shikonin (Shik) and its mechanism, murine macrophage-like RAW264.7 cells (RAW264.7 cells) were divided into control group, LPS group (0.125, 0.25 and 0.5μg/ml), LPS (0.125, 0.25 and 0.5μg/ml) plus Shik (0.5, 1 and 2μM) group, and Shik (2μM) group. After exposure for 24h, the le...

journal_title：International immunopharmacology

authors： Yang Y,Wang J,Yang Q,Wu S,Yang Z,Zhu H,Zheng M,Liu W,Wu W,He J,Chen Z

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:2,3,5,6-Tetramethylpyrazine (TMP) is known as a composition of Ephedra sinica and it has been used in the treatment of several disorders such as asthma, heart failure, rhinitis, and urinary incontinence. It has been reported that TMP inhibits melanoma metastasis and suppression angiogenesis by VEGF. OBJECTI...

journal_title：International immunopharmacology

authors： Yeom GG,Min S,Kim SY

更新日期：2014-02-01 00:00:00

abstract：:Glycopyrronium bromide (GB) is a muscarinic receptor antagonist that has been used as a long-acting bronchodilator in chronic obstructive pulmonary disease (COPD) patients. The aim of this study was to investigate the anti-inflammatory activity of inhaled GB in a cigarette smoke-induced acute lung inflammation mouse m...

journal_title：International immunopharmacology

authors： Shen LL,Liu YN,Shen HJ,Wen C,Jia YL,Dong XW,Jin F,Chen XP,Sun Y,Xie QM

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:Endothelin 1 (EDN1) is a strong angiogenic and mitogenic factor, playing a key role in hypervascularization, thyroid follicle cell hyperplasia, and lymphocyte infiltration in the thyroid gland of patients with Graves' disease (GD). EDN1 induces angiogenesis and mitogenesis via endothelin receptor type A (EDNRA)...

journal_title：International immunopharmacology

authors： Aydın AF,Develi-İş S,Doğru-Abbasoğlu S,Vural P,Ozderya A,Karadağ B,Uysal M

更新日期：2014-01-01 00:00:00

abstract：:Cartilage degradation is the most predominant pathological change during osteoarthritis (OA). Furthermore, accumulating evidence suggests that an excess of matrix metalloproteinase-13 (MMP-13) plays a critical role in the breakdown of cartilage. Here, the effects of Icariin on the expression of MMP-13 in IL-1β-induced...

journal_title：International immunopharmacology

authors： Zeng L,Wang W,Rong XF,Zhong Y,Jia P,Zhou GQ,Li RH

更新日期：2014-01-01 00:00:00

abstract：:Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds an...

journal_title：International immunopharmacology

authors： Colomeu TC,Figueiredo D,Cazarin CB,Schumacher NS,Maróstica MR Jr,Meletti LM,Zollner RL

更新日期：2014-01-01 00:00:00

abstract：:Oridonin is a natural compound purified from Rabdosia rubescens that has remarkable anti-inflammatory and antitumor activities. Although oridonin has been used in traditional Chinese medicine for many years to treat inflammatory diseases, the underlying mechanisms of these activities are not well understood. In this p...

journal_title：International immunopharmacology

authors： Guo W,Zheng P,Zhang J,Ming L,Zhou C,Zhang S

更新日期：2013-12-01 00:00:00

abstract：:Curcumin, extracted from the rhizome of Curcuma longa, is known to possess anti-inflammatory activities. Despite the fact that neutrophils are key player cells in inflammation, the role of curcumin on neutrophil cell biology is not well documented and, in particular, how curcumin can alter primed neutrophils is unknow...

journal_title：International immunopharmacology

authors： Antoine F,Simard JC,Girard D

更新日期：2013-12-01 00:00:00

abstract：:Our group recently reported the strong anti-inflammatory effects of geniposide (Gen), a bioactive iridoid glucoside derived from gardenia jasminoides, in a mouse acute lung injury model. Herein, we hypothesized that Gen might also have potential therapeutic benefits in treatment of asthma, which was tested in a mouse ...

journal_title：International immunopharmacology

authors： Deng Y,Guan M,Xie X,Yang X,Xiang H,Li H,Zou L,Wei J,Wang D,Deng X

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:The molecular mechanism responsible for the immunomodulatory effect of 1,25-dihydroxyvitamin D3 (Vit-D) is still not well elucidated. Unavoidable systemic toxicity of Vit-D has encouraged to develop more potent and less toxic Vit-D analogs, such as 1,25-dihydroxyvitamin D3-3-bromoacetate (BE). Our aim was to ex...

journal_title：International immunopharmacology

authors： Datta-Mitra A,Mitra A,Ray R,Raychaudhuri SP,Kundu-Raychaudhuri S

更新日期：2013-11-01 00:00:00

abstract：UNLABELLED:The mechanistic implications of the presence of sympathetic noradrenergic innervation in lymphoid organs in synaptic association with lymphocytes open to the influence of hormonal fluctuations throughout reproductive age in females has not been investigated yet. OBJECTIVES:The aim of the present study is to...

journal_title：International immunopharmacology

authors： Priyanka HP,ThyagaRajan S

更新日期：2013-11-01 00:00:00

abstract：:The aim of this study was to evaluate possible association between ophthalmic complications in sulfur mustard (SM) exposed patients with mild ocular injuries and serum soluble adhesion molecules. Serum levels of sICAM-1, sL-selectin, sP-selectin and sE-selectin in 367 SM-exposed individuals with or without eye injurie...

journal_title：International immunopharmacology

authors： Ghasemi H,Yaraee R,Hassan ZM,Faghihzadeh S,Soroush MR,Pourfarzam S,Ebtekar M,Babaei M,Moaiedmohseni S,Naghizadeh MM,Askari N,Ghazanfari T

更新日期：2013-11-01 00:00:00

abstract：:To study the effects of Taishan Pinus massoniana pollen polysaccharides (TPPPS) on Bordetella avium outer membrane protein A (ompA) recombinant protein vaccine, ompA was expressed, confirmed by Western blotting and mixed with TPPPS. Female BALB/c mice were randomly divided into six groups (I-VI). Groups I, II, and III...

journal_title：International immunopharmacology

authors： Zhao X,Liang M,Yang P,Guo F,Pan D,Huang X,Li Y,Wu C,Qu T,Zhu R

更新日期：2013-11-01 00:00:00

abstract：:Inflammatory/pro-resorptive cytokines and chemokines form part of a complex inter-dependent network and may be influenced by vitamin D. We investigated their inter-relationship and the effect of a loading dose of vitamin D. We measured plasma concentrations of an array of cytokines including tumour necrosis factor-alp...

journal_title：International immunopharmacology

authors： Karim Y,Turner C,Dalton N,Roplekar R,Sankaralingam A,Ewang M,Fogelman I,Hampson G

更新日期：2013-11-01 00:00:00

abstract：:Extracellular adenosine triphosphate (ATP) is sequentially dephosphorylated by two ectoenzymes: CD39/nucleotidase triphosphate dephosphorylase (ENTPD) and CD73/5'-ectonucleotidase (5'-NT). Adenosine, its notable metabolite, may elicit potent anti-inflammatory responses. We examined whether the CD39-adenosinergic axis ...

journal_title：International immunopharmacology

authors： Nemoto E,Gotoh K,Tsuchiya M,Sakisaka Y,Shimauchi H

更新日期：2013-11-01 00:00:00

abstract：:Streptococcus pyogenes is a common colonizer of the mucosal layers in the mouth, nose, and pharynx but it is also a major Gram-positive human pathogen that causes infections ranging from pharyngitis to severe systemic diseases. The lactobacilli colonize the oral tracts and are known to protect against colonization by ...

journal_title：International immunopharmacology

authors： Rizzo A,Losacco A,Carratelli CR,Domenico MD,Bevilacqua N

更新日期：2013-10-01 00:00:00

abstract：:Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to ...

journal_title：International immunopharmacology

authors： Amirshahrokhi K

更新日期：2013-10-01 00:00:00

abstract：:An emerging role is postulated for IL-17-producing thymocytes, which in their majority consist of IL-17-producing CD4(+) cells. For these, a specific role in the immediate defense against infectious pathogens is suggested, independent from the development of an adaptive immune response in the immune periphery. Immune ...

journal_title：International immunopharmacology

authors： Weber A,Zimmermann C,Mausberg AK,Kieseier BC,Hartung HP,Hofstetter HH

更新日期：2013-10-01 00:00:00

abstract：:In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammator...

journal_title：International immunopharmacology

authors： Cho IJ,Lee CW,Lee MY,Kang MR,Yun J,Oh SJ,Han SB,Lee K,Park SK,Kim HM,Jung SH,Kang JS

更新日期：2013-08-01 00:00:00

abstract：:γδ T cells account for approximately 5% of peripheral blood T cells but are more abundant in mucosal tissue. Based on the recognized ligands and their general lack of MHC restriction, γδ T cells are considered as unconventional T cells that link innate and adaptive immunity. γδ T cells produce a diverse range of cytok...

journal_title：International immunopharmacology

authors： Kabelitz D,Peters C,Wesch D,Oberg HH

更新日期：2013-07-01 00:00:00

abstract：:A recently discovered population of lymphocytes, called T regulatory cells (Tregs), is characterized by expression of transcription factor Forkhead box P3 (FoxP3). These cells have been successfully used as therapeutic treatments and prophylaxis for graft-versus-host disease (GVHD) and diabetes and might become an att...

journal_title：International immunopharmacology

authors： Gołąb K,Krzystyniak A,Marek-Trzonkowska N,Misawa R,Wang LJ,Wang X,Cochet O,Tibudan M,Langa P,Millis JM,Trzonkowski P,Witkowski P

更新日期：2013-07-01 00:00:00

abstract：:Senescence is an irreversible growth arrest which can be triggered by stresses such as oxidative reaction, telomere shortening, DNA damage, or oncogene signaling. Oxidative stress accelerates vascular endothelial cell senescence, and may promote atherosclerosis in humans. Interleukin-8 (IL-8) has been shown to play an...

journal_title：International immunopharmacology

authors： Shen XH,Xu SJ,Jin CY,Ding F,Zhou YC,Fu GS

更新日期：2013-06-01 00:00:00

abstract：:Icaritin, an intestinal metabolite of prenylflavonoids from Herba Epimedii, has been known to regulate many cellular processes. The purpose of this study was to investigate the protective effects of icaritin on inflammation in lipopolysaccharide (LPS) stimulated mouse peritoneal macrophages in vitro and zymosan induce...

journal_title：International immunopharmacology

authors： Lai X,Ye Y,Sun C,Huang X,Tang X,Zeng X,Yin P,Zeng Y

更新日期：2013-05-01 00:00:00

abstract：:The effect of pifithrin (PFT)-α, a pharmacological inhibitor of p53, on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophage-like cells was examined. PFT-α inhibited the production of NO but not tumor necrosis factor (TNF)-α in response to LPS. PFT-α inhibited LPS-induced NO production...

journal_title：International immunopharmacology

authors： Mendjargal A,Odkhuu E,Koide N,Nagata H,Kurokawa T,Nonami T,Yokochi T

更新日期：2013-04-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) isolated from different tissue sources may present distinct immunomodulatory profiles. As lymphocyte responses are a combination of several distinct steps, we evaluated and compared the impact of MSCs from different sources on the activation, proliferation and migration of T-cells. We ...

journal_title：International immunopharmacology

authors： Najar M,Raicevic G,Fayyad-Kazan H,De Bruyn C,Bron D,Toungouz M,Lagneaux L

更新日期：2013-04-01 00:00:00

abstract：:A considerable fraction of renal transplanted patients is susceptible to humoral rejection. Today well-established therapy regimens are available to control antibody-mediated rejection in the short term. Nevertheless, donor-specific antibodies persist and graft function deteriorates over time. This might be due to ins...

journal_title：International immunopharmacology

authors： Matz M,Lehnert M,Lorkowski C,Fabritius K,Weber UA,Mashreghi MF,Neumayer HH,Budde K

更新日期：2013-04-01 00:00:00

abstract：:Flavonoids are a class of compounds that exist in nature with the structure of 2-phenyl-chromone. In Chinese traditional medicine, herbal drugs containing flavonoids are widely used for the treatment of inflammation, cardiovascular disease, tumor and so on. In this study, we investigated the anti-inflammatory effect a...

journal_title：International immunopharmacology

authors： Xu J,Jia YY,Chen SR,Ye JT,Bu XZ,Hu Y,Ma YZ,Guo JL,Liu PQ

更新日期：2013-04-01 00:00:00

abstract：:Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activ...

journal_title：International immunopharmacology

authors： Yoon TJ,Lee SJ,Kim EY,Cho EH,Kang TB,Yu KW,Suh HJ

更新日期：2013-04-01 00:00:00

abstract：:Extracts of leaves of different species of the genus Combretum have been used historically to treat a variety of medicinal problems. However, little is known about the active components conferring therapeutic properties to these extracts. In the present studies, we evaluated biochemical properties and immunomodulatory...

journal_title：International immunopharmacology

authors： Schepetkin IA,Kouakou K,Yapi A,Kirpotina LN,Jutila MA,Quinn MT

更新日期：2013-03-01 00:00:00

abstract：:Mast cells play a critical role during the development of an allergic response. Upon activation by an antigen and IgE, via FcεRI receptors, mast cells release histamine and other mediators that initiate and propagate immediate hypersensitivity reactions. Mast cells also secrete cytokines that regulate the immune respo...

journal_title：International immunopharmacology

authors： de Souza Santos M,Jonis Andrioli W,Freire de Morais Del Lama MP,Kenupp Bastos J,Nanayakkara NP,Zumstein Georgetto Naal RM

更新日期：2013-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has emerged as a common public health problem that can progress to end-stage liver disease. Although the function of aquaglyceroporin-9 (AQP9) as a glycerol channel has been proven, the mechanism of AQP9 in the development of NAFLD is poorly understood. To investigate the effe...

journal_title：International immunopharmacology

authors： Cai C,Wang C,Ji W,Liu B,Kang Y,Hu Z,Jiang Z

更新日期：2013-03-01 00:00:00

abstract：:To examine the mechanisms of diabetes-enhanced inflammation, ear inflammation was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in streptozotocin (STZ)-injected diabetic and control mice. The inflammatory response was determined from ear thickness and histology. The mRNA expression of several inflammation-rela...

journal_title：International immunopharmacology

authors： Iba Y,Watanabe K,Ozaki K,Aozasa O,Ishizawa K,Matsuura T,Oyama H,Masukawa T

更新日期：2013-03-01 00:00:00

abstract：:B cell activating factor (BAFF), a member of the tumor necrosis factor family, is critical to B cell survival, proliferation, maturation, and immunoglobulin secretion and to T cell activation. In the present study, the full-length cDNA of BAFF from the South African clawed frog (Xenopus laevis, designated xlBAFF) was ...

journal_title：International immunopharmacology

authors： Yang L,Zhou L,Zong X,Cao X,Ji X,Gu W,Zhang S

更新日期：2013-03-01 00:00:00

abstract：:Angiogenesis plays a crucial role at the early stage of tumorigenesis and tumor progression. A suitable model will be useful not only for the clarification of the underlying molecular mechanisms, but also for high-throughput identification of novel anti-angiogenesis compounds. Here, we established a zebrafish model fo...

journal_title：International immunopharmacology

authors： Yang XJ,Chen GL,Yu SC,Xu C,Xin YH,Li TT,Shi Y,Gu A,Duan JJ,Qian C,Cui YH,Zhang X,Bian XW

更新日期：2013-02-01 00:00:00